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Evaluation of Resveratrol, Green Tea Extract, Curcumin, Oxaloacetic Acid, and Medium-Chain Triglyceride Oil on Life Span of Genetically Heterogeneous Mice

2012; Oxford University Press; Volume: 68; Issue: 1 Linguagem: Inglês

10.1093/gerona/gls070

1758-535X

Randy Strong, Richard A. Miller, Clinton M. Astle, Joseph A. Baur, Rafael de Cabo, Eduardo Fernández, Wen Guo, Martin A. Javors, James L. Kirkland, James F. Nelson, David Sinclair, Bruce Teter, D. Williams, Nurulain T. Zaveri, Nancy L. Nadon, David E. Harrison,

Sirtuins and Resveratrol in Medicine

B Y delaying or reducing the onset of multiple late-life diseases, treatments that increase longevity could have a far greater benefi t to quality of life than treatments targeted at single late-life diseases such as cancer or heart disease ( 1 -3 ).There are numerous reports of dietary additives purported to have benefi cial effects in rodent models ( 4 -6 ), but until recently none have been replicated and accepted by the scientifi c community as a reliable and reproducible result.In 2003, the National Institute on Aging established the NIA Interventions Testing Program (ITP) to evaluate agents that are hypothesized to delay aging in laboratory mice and thus prevent or delay multiple diseases of late life.The central features of the ITP protocol have been described elsewhere ( 7 -11 ).Briefl y, test agents are nominated by members of the scientifi c community whose recommendations are reviewed by an expert committee.