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Theranostic nanoemulsions: codelivery of hydrophobic drug and hydrophilic imaging probe for cancer therapy and imaging

2014; Future Medicine; Volume: 9; Issue: 18 Linguagem: Inglês

10.2217/nnm.14.50

1748-6963

Xinggang Yang, Dun Wang, Yan Ma, Qiang Zhao, John K. Fallon, Dan Liu, Xian Xu, Yongjun Wang, Zhonggui He, Feng Liu,

RNA Interference and Gene Delivery

Aim: To develop a theranostic nanoemulsion (TNE) that can codeliver the conjugates of a hydrophobic drug paclitaxel (PTX) and a hydrophilic imaging probe sulforhodamine B (SRB). Materials & methods: The TNE was established using core-matched technology, and can achieve high encapsulation efficiency and synchronized release of the loaded cargo. It has been examined for a correlation between the dynamic uptake of PTX and the intensity of SRB imaging signal in different organs. Results & discussion: Our data demonstrate that the TNE, with improved circulation time, increases therapeutic efficacy and imaging efficiency in both drug-sensitive and drug-resistant cancer. The TNE could not satisfy the demand of visual diagnosis in the living animal because of interference. We therefore formulated a long-circulating theranostic nanoemulsion (LCTNE). Results showed that the LCTNE can meet imaging requirements in vivo. Conclusion: The LCTNE plays a good therapeutic and diagnostic role for subcutaneous tumors in the living animal.