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ArchAlign: Coordinate-free chromatin alignment reveals novel architectures

2010; BioMed Central; Volume: 11; Issue: 12 Linguagem: Inglês

10.1186/gb-2010-11-12-r126

1474-760X

William Lai, Michael Buck,

Plant Molecular Biology Research

Abstract To facilitate identification and characterization of genomic functional elements, we have developed a chromatin architecture alignment algorithm (ArchAlign). ArchAlign identifies shared chromatin structural patterns from high-resolution chromatin structural datasets derived from next-generation sequencing or tiled microarray approaches for user defined regions of interest. We validated ArchAlign using well characterized functional elements, and used it to explore the chromatin structural architecture at CTCF binding sites in the human genome. ArchAlign is freely available at http://www.acsu.buffalo.edu/~mjbuck/ArchAlign.html .