Combination Antiviral Therapy for Influenza: Predictions From Modeling of Human Infections
2012; Oxford University Press; Volume: 205; Issue: 11 Linguagem: Inglês
10.1093/infdis/jis265
ISSN1537-6613
AutoresAlan S. Perelson, Libin Rong, Frederick G. Hayden,
Tópico(s)Animal Disease Management and Epidemiology
ResumoEmergence of resistance is a major concern in influenza antiviral treatment and prophylaxis. Combination antiviral therapy might overcome this problem. Here, we estimate that all possible single mutants and a sizeable fraction of double mutants are generated during an uncomplicated influenza infection. While most of them may sustain a fitness cost, some variants may confer drug resistance and be selected during therapy. We argue that a triple combination regimen would markedly reduce the risk of antiviral resistance emergence in seasonal and pandemic influenza viruses, especially in seriously ill or immunocompromised hosts.
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