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Effective Hemostasis During Minor Surgery in a Case of Hereditary Combined Deficiency of Vitamin K-dependent Clotting Factors

2009; SAGE Publishing; Volume: 16; Issue: 2 Linguagem: Inglês

10.1177/1076029608330473

1938-2723

Mario Lapecorella, Mariasanta Napolitano, Francesco Bernardi, Mirko Pinotti, Piero Sandro Sbrighi, Giovanna Marchetti, Alessandro Canella, Pierpaolo Caruso, Assunta Orecchioni, Guglielmo Mariani,

Atrial Fibrillation Management and Outcomes

Combined deficiency of the vitamin K-dependent clotting factors (VKCFD) is a rare bleeding disorder involving defective gamma-carboxylation of coagulation factors II , VII, IX and X as well as natural anticoagulants protein C and protein S. The disease is characterized by a cluster of different, often life threatening, bleeding symptoms occurring both spontaneously and in a surgical setting. In the present paper we describe two different treatment modalities to be used both in a programmed surgical procedure and in an emergency scenario. As this disease is a natural model that resembles oral anticoagulation, our experience discloses a possible rationale in the use of recombinant activated FVII for warfarin reversal.