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Roles of adipocyte derived hormone adiponectin and resistin in insulin resistance of type 2 diabetes

2006; Baishideng Publishing Group; Volume: 12; Issue: 11 Linguagem: Inglês

10.3748/wjg.v12.i11.1747

2219-2840

Huiling Lü,

Regulation of Appetite and Obesity

P < 0.05); furthermore, the levels of resistin in obese diabetes group were increased significantly compared to that in non-obese diabetes group (P < 0.05).Plasma adiponectin was correlated negatively with BMI, blood glucose, insulin resistance index and triglyceride (respectively, r = -0.55,P < 0.01; r = -0.51,P < 0.05; r = -0.52,P < 0.05；r = -0.39,P < 0.05), while it was positively cor- related with insulin sensitive index (r=0.45,P < 0.05).Conversely, plasma resistin correlated positively with BMI, blood glucose, triglyceride and insulin resistance index (respectively, r = 0.40, P < 0.05; r = 0.52, P < 0.05; r = 0.46, P < 0.01; r = 0.27, P < 0.05), and negatively correlated with insulin sensitive index (r = -0.32,P < 0.05).CONCLUSION: Plasma adiponectin and resistin are associated with the disorder of metabolism of glucose and lipid in diabetes.The relationship between these hormone and insulin sensitivity suggests that they may take part in the development of insulin resistance of type 2 diabetes.