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The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis

2013; Public Library of Science; Volume: 10; Issue: 6 Linguagem: Inglês

10.1371/journal.pmed.1001474

1549-1676

Tove Fall, Sara Hägg, Reedik Mägi, Alexander Ploner, Krista Fischer, Momoko Horikoshi, Antti‐Pekka Sarin, Guðmar Þorleifsson, Claes Ladenvall, Mart Kals, Maris Kuningas, Harmen H. M. Draisma, Janina S. Ried, Natalie R. van Zuydam, Ville Huikari, Massimo Mangino, Emily Sonestedt, Beben Benyamin, Christopher P. Nelson, Natalia V. Rivera, Kati Kristiansson, Huei-Yi Shen, Aki S. Havulinna, Abbas Dehghan, Louise A. Donnelly, Marika Kaakinen, Marja-Liisa Nuotio, Neil Robertson, Renée F.A.G. de Bruijn, M. Arfan Ikram, Najaf Amin, Anthony J. Balmforth, Peter S. Braund, Alex S. F. Doney, Angela Döring, Paul Elliott, Tõnu Esko, Oscar H. Franco, Sólveig Grétarsdóttir, Anna‐Liisa Hartikainen, Kauko Heikkilä, Karl‐Heinz Herzig, Hilma Hólm, Jouke‐Jan Hottenga, Elina Hyppönen, Thomas Illig, Aaron Isaacs, Bo Isomaa, Lennart C. Karssen, Johannes Kettunen, Wolfgang Köenig, Kari Kuulasmaa, Tiina Laatikainen, Jaana Laitinen, Cecilia M. Lindgren, Valeriya Lyssenko, Esa Läärä, Nigel W. Rayner, Satu Männistö, Anneli Pouta, Wolfgang Rathmann, Fernando Rivadeneira, Aimo Ruokonen, Markku J. Savolainen, Eric J.G. Sijbrands, Kerrin S. Small, Jan Smit, Valgerður Steinthórsdóttir, Ann‐Christine Syvänen, Anja Taanila, Martin D. Tobin, André G. Uitterlinden, Sara M. Willems, Gonneke Willemsen, Jacqueline C.M. Witteman, Markus Perola, Alun Evans, Jean Ferrières, Jarmo Virtamo, Frank Kee, David‐Alexandre Trégouët, Dominique Arveiler, Philippe Amouyel, Maurizio Ferrario, Paolo Brambilla, Alistair S. Hall, Andrew C. Heath, Pamela A. F. Madden, Nicholas G. Martin, Grant W. Montgomery, John B. Whitfield, Antti Jula, Paul Knekt, Ben A. Oostra, Cornelia M. van Duijn, Brenda W.J.H. Penninx, George Davey Smith, Jaakko Kaprio, Nilesh J. Samani, Christian Gieger, Annette Peters, H.‐Erich Wichmann, Dorret I. Boomsma, Eco J. C. de Geus, Jaakko Tuomilehto, Chris Power, Christopher J. Hammond, Tim D. Spector, Lars Lind, Marju Orho‐Melander, Colin N. A. Palmer, Andrew D. Morris, Leif Groop, Marjo‐Riitta Järvelin, Veikko Salomaa, Erkki Vartiainen, Albert Hofman, Samuli Ripatti, Andres Metspalu, Unnur Þorsteinsdóttir, Kāri Stefánsson, Nancy L. Pedersen, Mark I. McCarthy, Erik Ingelsson, Inga Prokopenko,

Cardiovascular Function and Risk Factors

In this study, Prokopenko and colleagues provide novel evidence for causal relationship between adiposity and heart failure and increased liver enzymes using a Mendelian randomization study design. Please see later in the article for the Editors' Summary