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Growth Enhancement of Transgenic Mice Expressing Human Insulin-Like Growth Factor I*

1988; Oxford University Press; Volume: 123; Issue: 6 Linguagem: Inglês

10.1210/endo-123-6-2827

1945-7170

Lawrence S. Mathews, Robert E. Hammer, Richard R. Behringer, A. Joseph D’Ercole, Graeme I. Bell, Ralph L. Brinster, Richard D. Palmiter,

Growth Hormone and Insulin-like Growth Factors

A line of transgenic mice carrying a chimeric gene composed of human insulin-like growth factor I (IGF-I) coding sequences fused to the mouse metallothionein I promoter was generated to study the effects of chronically elevated exposure to IGF-I. Mice in this line overexpress IGF-I in most tissues studied and have circulating IGF-I levels 1.5 times the normal value. This results in a growth response manifested by a 1.3-fold increase in weight as a result of selective organomegaly without an apparent increase in skeletal growth. In addition, expression of the endogenous GH and IGF-I genes is inhibited. These results are consistent with IGF-I playing an important role in the control of somatic growth. (Endocrinology123: 2827–2833, 1988)