Teicoplanin therapy for Staphylococcus aureus septicaemia: relationship between pre-dose serum concentrations and outcome
2000; Oxford University Press; Volume: 45; Issue: 6 Linguagem: Inglês
10.1093/jac/45.6.835
ISSN1460-2091
AutoresIan Harding, Alasdair MacGowan, L. O. White, Elizabeth Darley, V. Reed,
Tópico(s)Bacterial Identification and Susceptibility Testing
ResumoLogistic regression analysis was performed on data drawn from a clinical trials database for Staphylococcus aureus septicaemia treated with teicoplanin. Variables analysed were age, body weight, mean pre-dose and post-dose serum teicoplanin concentrations, mean dose (mg or mg/kg body weight) and combination versus monotherapy. Only two variables correlated with clinical outcome at a significance level better than 0.05: age (P = 0.012) and mean pre-dose serum concentration (P = 0.010). The probability of successful treatment declined with age and increased with mean pre-dose serum concentration.
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