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Hepatoprotective effect of Rosmarinus officinalis and rosmarinic acid on acetaminophen-induced liver damage

2014; United Arab Emirates University; Volume: 26; Issue: 10 Linguagem: Inglês

10.9755/ejfa.v26i10.17836

2079-0538

Rodrigo Lucarini, Wagner Antônio Bernardes, Marcos Gomide Tozatti, Ademar Alves da Silva Filho, Márcio Luís Andrade e Silva, Cláudia Momo, Antônio Eduardo Miller Crotti, Carlos Henrique Gomes Martins, Wilson Roberto Cunha,

Liver Disease Diagnosis and Treatment

The hydroalcoholic extract of the leaves of Rosmarinus officinalis (HE), a species of medicinal value, and its constituent rosmarinic acid (RA) were evaluated for hepatoprotective in the acetaminophen-induced liver damage model. Groups of Wistar albino rats (n=6) were pre-administered with HE (100, 250 and 500 mg/kg, p.o.) and RA (10, 25 and 50 mg/kg, p.o.) prior to a single dose of acetaminophen (APAP, 600 mg/kg body weight; p.o). The hepatoprotective activity of HE extract was observed through histopathological analysis and reduction of the level of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP). These observations were comparable to the normal group prior to APAP administration. Group that was treated with APAP alone exhibited high levels of transaminases and ALP. The obtained results from the present study suggested that HE may prevent APAP-induced hepatic injuries. RA did not displayed significant hepatoprotective activity against APAP-induced liver damage.