Artigo Revisado por pares

Discrepancies in Tuberculin Skin Test Results with Two Commercial Products in a Population of Intravenous Drug Users

1993; Oxford University Press; Volume: 168; Issue: 4 Linguagem: Inglês

10.1093/infdis/168.4.1048

ISSN

1537-6613

Autores

Alan R. Lifson, John K. Watters, Suzanne Thompson, Charles M. Crane, Fred Wise,

Tópico(s)

HIV/AIDS drug development and treatment

Resumo

Screening for tuberculosis (using the Mantoux test) and human immunodeficiency virus (HIV) was conducted among intravenous drug users (IVDUs) recruited from a San Francisco Bay Area neighborhood. Of 178 IVDUs skin-tested with one commercial purified protein derivative (PPD) preparation, a reaction of > or = 5 mm of induration occurred in 62 (47%) of 133 HIV-negative and 13 (29%) of 45 HIV-positive IVDUs (P = .037). Forty-two IVDUs with an initial PPD reaction > or = 5 mm were retested with a second commercial preparation; 11 (26%) had no reaction (0 mm) on retesting. These 11 were 5 (56%) of 9 HIV-positive and 6 (18%) of 33 HIV-negative persons (P = .038). These discrepancies may be unique to specific lots of product or may reflect more general differences. A degree of caution in evaluating unexpected tuberculin skin test results may be indicated. Response to different tuberculin products by HIV status should be further evaluated.

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