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Structure–activity delineation of quinones related to the biologically active Calothrixin B

2006; Elsevier BV; Volume: 17; Issue: 1 Linguagem: Inglês

10.1016/j.bmcl.2006.09.090

1464-3405

Paul H. Bernardo, Christina L. L. Chai, Maurice Le Guen, Geoffrey D. Smith, Paul Waring,

Enzyme function and inhibition

Quinones such as Calothrixins A and B display a range of biological properties. As part of our ongoing studies to elucidate the mechanism of action of the Calothrixins, several related quinones were synthesized and tested for biological activity. The results of the structure-activity relationship (SAR) studies are reported here.