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The role of the 5-HT3 antagonists ondansetron and dolasetron in the control of delayed onset nausea and vomiting in patients receiving moderately emetogenic chemotherapy

1997; Elsevier BV; Volume: 8; Issue: 2 Linguagem: Inglês

10.1023/a

1569-8041

Joseph L. Pater, W. Lofters, Benny Zee, E. Dempsey, David Walde, Jean Pierre Moquin, K Wilson, Paul Hoskins, R. Guévin, Savita Verma, Rudolph M. Navari, James E. Krook, John D. Hainsworth, Michael Palmer, Christine Chin,

Pathogenesis and Treatment of Hiccups

Background: 5-HT 3 antagonists are effective in reducing the acute nausea and vomiting caused by cancer chemotherapy.However, it is not clear whether continuing these agents beyond twenty four hours is useful in controlling emesis on days two to seven after chemotherapy.Patients and methods: Four hundred seven patients receiving moderately emetogenic chemotherapy who had been given dexamethasone 8 mg i.v. and either ondansetron 32 mg i.v. or dolasetron 2.4 mg/kg i.v. were randomized to continue either an oral form of their 5-HT 3 antagonist (ondansetron 8 mg b.i.d. or dolasetron 200 mg daily) plus dexamethasone 8 mg p.o. daily or dexamethasone alone for days two to seven.Endpoints assessed by self-report were: 1) complete control (no vomiting, no rescue medications, no missing data) of emesis; 2) nausea severity; and 3) quality-of-life as measured by the EORTC QLQ-C30.Results: Continuation of 5-HT 3 antagonists improved slightly, but not significantly, the complete control rate (47% vs. 41%; P = 0.24 one-sided) after chemotherapy.However, mean nausea severity was significantly (P = 0.015 one sided) reduced (by 3 mm on a 10 cm scale) on the combined arm.Minimal differences in quality of life were observed. Conclusion:The benefit of continuing 5-HT 3 antagonists beyond 24 hours is modest and the merits of routine use in these circumstances debatable.