The Th1 life cycle: molecular control of IFN-γ to IL-10 switching
2011; Elsevier BV; Volume: 32; Issue: 6 Linguagem: Inglês
10.1016/j.it.2011.03.010
ISSN1471-4981
AutoresAndrew P. Cope, Gaëlle Le Friec, John Cardone, Claudia Kemper,
Tópico(s)Immune Cell Function and Interaction
ResumoControl of IFN-γ-secreting T helper (Th) 1 cells prevents autoimmunity and immunopathology during infection. IL-10-mediated suppression of Th1 cells is achieved not only through IL-10 produced extrinsically, but also through a negative feedback loop that induces "intrinsic" IL-10 expression in cells also expressing IFN-γ, during Th1 lineage differentiation. Targeting this Th1 cell IFN-γ to IL-10 switching is a tantalising prospect for developing therapeutics for Th1-mediated diseases. In this review, the molecular pathways that regulate IFN-γ versus IL-10 expression in Th1 cells are examined, with focus on the role of complement regulator and T cell co-stimulatory molecule CD46, and also discussed are challenges and controversies in the field.
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