Development and influence of inhibition in the lateral superior olivary nucleus
2000; Elsevier BV; Volume: 147; Issue: 1-2 Linguagem: Inglês
10.1016/s0378-5955(00)00119-2
ISSN1878-5891
Autores Tópico(s)Neurobiology and Insect Physiology Research
ResumoWhile studies of neuronal development and plasticity have focused on excitatory pathways, the inhibitory projection from the MNTB to the LSO provides a favorable model for studies of synaptic inhibition. This review covers recent studies from our laboratories indicating that inhibitory connections are quite dynamic during development. These findings suggest that there are two phases inhibitory transmission. During an initial depolarizing phase is growth and branching of pre- and postsynaptic elements in the LSO. During a second hyperpolarizing phase there is refinement of inhibitory afferent arborizations and the LSO dendrites that they innervate.
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