Editorial Revisado por pares

Epigenetic Gene Regulation: Early Environmental Exposures

2006; Future Medicine; Volume: 8; Issue: 1 Linguagem: Inglês

10.2217/14622416.8.1.5

ISSN

1744-8042

Autores

Dana C. Dolinoy,

Tópico(s)

Birth, Development, and Health

Resumo

PharmacogenomicsVol. 8, No. 1 EditorialEpigenetic gene regulation: early environmental exposuresDana C DolinoyDana C DolinoyDuke University Medical Center, Department of Radiation Oncology, University Program in Genetics and Genomics, and Integrated Toxicology Program, Box 3433, Durham, NC 27710, USA. Published Online:22 Dec 2006https://doi.org/10.2217/14622416.8.1.5AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInRedditEmail View articleBibliography1 Bateson P, Barker D, Clutton-Brock T et al.: Developmental plasticity and human health. Nature430(6998),419–421 (2004).Crossref, Medline, CAS, Google Scholar2 Barker D: The developmental origins of insulin resistance. Hormone Res.64(S3),2–7 (2005).Crossref, Medline, CAS, Google Scholar3 Barker D, Bagby S, Hanson M: Mechanisms of disease: in utero programming in the pathogenesis of hypertension. Nat. Clin. Pract. Nephrol.2,700–707 (2006).Crossref, Medline, Google Scholar4 Barker DJP, Osmond C, Forsen TJ, Kajantie E, Eriksson JG: Trajectories of growth among children who gave coronary events as adults. N. Engl J. Med.353(17),1802–1809 (2005).Crossref, Medline, CAS, Google Scholar5 Waterland RA, Lin J-R, Smith CA, Jirtle RL: Post-weaning diet affects genomic imprinting at the insulin-like growth factor 2 (Igf2) locus. Hum. Mol. Genet.15(5),705–716 (2006).Crossref, Medline, CAS, Google Scholar6 Li S, Hursting S, Davis B, McLachlan J, Barrett J: Environmental exposure, DNA methylation, and gene regulation: lessons from diethylstilbesterol-induced cancers. Ann. NY Acad. Sci.983(1),161–169 (2003).Crossref, Medline, CAS, Google Scholar7 Waterland R, Jirtle R: Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases. Nutrition20(1),63–68 (2004).Crossref, Medline, CAS, Google Scholar8 Cooney CA, Dave AA, Wolff GL: Maternal methyl supplements in mice affect epigenetic variation and DNA methylation of offspring. J. Nutr.132(8),S2393–S2400 (2002).Crossref, Medline, CAS, Google Scholar9 Silva Lima B, Van der Laan J: Mechanisms of nongenotoxic carcinogenesis and assessment of the human hazard. Regul. Toxicol. Pharmacol.32(2),135–143 (2000).Crossref, Medline, Google Scholar10 Murphy SK, Jirtle RL: Imprinting evolution and the price of silence. Bioessays25(6),577–588 (2003).Crossref, Medline, CAS, Google Scholar11 Jiang Y-h, Bressler J, Beaudet AL: Epigenetics and human disease. Annu. Rev. Genomics Hum. Genet.5(1),479–510 (2004).Crossref, Medline, CAS, Google Scholar12 Petronis A: The origin of schizophrenia: genetic thesis, epigenetic antithesis, and resolving synthesis. Biol. Psychiatry55(10),965–970 (2004).Crossref, Medline, CAS, Google Scholar13 Vercelli D: Genetics, epigenetics, and the environment: switching, buffering, releasing. J. Allergy Clin. Immunol.113(3),381–386 (2004).Crossref, Medline, CAS, Google Scholar14 Rakyan VK, Preis J, Morgan HD, Whitelaw E: The marks, mechanisms and memory of epigenetic states in mammals. Biochem. J.356,1–10 (2001).Crossref, Medline, CAS, Google Scholar15 Druker R, Bruxner TJ, Lehrbach NJ, Whitelaw E: Complex patterns of transcription at the insertion site of a retrotransposon in the mouse. Nucl. Acids Res.32(19),5800–5808 (2004).Crossref, Medline, CAS, Google Scholar16 Rakyan VK, Blewitt ME, Druker R, Preis JI, Whitelaw E: Metastable epialleles in mammals. Trends Genet.18(7),348–351 (2002).Crossref, Medline, CAS, Google Scholar17 Dolinoy DC, Wiedman J, Waterland R, Jirtle RL: Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome. Environ. Health Perspect.114(4),567–572 (2006).Crossref, Medline, CAS, Google Scholar18 Waterland R, Dolinoy DC, Lin J-R, Smith CA, Shi X, Tahiliani K: Maternal methyl supplements increase offspring DNA methylation at Axin(fused). Genesis44(9),401–406 (2006).Crossref, Medline, CAS, Google Scholar19 Waterland R, Jirtle R: Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol. Cell Biol.23(15),5293–5300 (2003).Crossref, Medline, CAS, Google Scholar20 Duhl D, Vrieling H, Miller K, Wolff G, Barsh G: Neomorphic agouti mutations in obese yellow mice. Nat. Genet.8(1),59–65 (1994).Crossref, Medline, CAS, Google Scholar21 Morgan H, Sutherland H, Martin D, Whitelaw E: Epigenetic inheritance at the agouti locus in the mouse. Nat. Genet.23(3),314–318 (1999).Crossref, Medline, CAS, Google Scholar22 Miltenberger R, Mynatt R, Wilkinson J, Woychik R: The role of the agouti gene in the Yellow Obese Syndrome. J. Nutr.127(9),S1902–S1907 (1997).Crossref, Medline, CAS, Google Scholar23 Cropley JE, Suter CM, Beckman KB, Martin DIK: From the cover: germ-line epigenetic modification of the murine Avy allele by nutritional supplementation. Proc. Natl Acad. Sci. USA103(46),17308–17312 (2006).Crossref, Medline, CAS, Google Scholar24 Li S, Hansman R, Newbold R, Davis B, McLachlan JA, Barrett JC: Neonatal diethylstilbestrol exposure induces persistent elevation of c-fos expression and hypomethylation in its exon-4 in mouse uterus. Mol. Carcinog.38(2),78–84 (2003).Crossref, Medline, CAS, Google Scholar25 Ho S, Tang W, Belmonte de Frausto J, Prins G: Developmental exposure to estradiol and bisphenol a increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4. Cancer Res.66(11),5624–5632 (2006).Crossref, Medline, CAS, Google Scholar26 Weaver I, Cervoni N, Champagne FA et al.: Epigenetic programming by maternal behavior. Nat. Neurosci.7(8),847–854 (2004).Crossref, Medline, CAS, Google Scholar27 Weaver ICG, Meaney MJ, Szyf M: Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood. Proc. Natl Acad. Sci. USA103(9),3480–3485 (2006).Crossref, Medline, CAS, Google Scholar28 Rossignol S, Steunou V, Chalas C et al.: The epigenetic imprinting defect of patients with Beckwith–Wiedemann syndrome born after assisted reproductive technology is not restricted to the 11p15 region. J. Med. Genet. 43(12),902–907 (2006).Crossref, Medline, CAS, Google Scholar29 Niemitz E, Feinberg A: Epigenetics and assisted reproductive technology: a call for investigation. Am. J. Hum. Genet.74(4),599–609 (2004).Crossref, Medline, CAS, Google Scholar30 Barcellos-Hoff MH: It takes a tissue to make a tumor: epigenetics, cancer and the microenvironment. J. Mammary Gland Biol. Neoplasia6(2),213–221 (2001).Crossref, Medline, CAS, Google Scholar31 Weaver I, Champagne FA, Brown S et al. Reversal of maternal programming of stress responses in adult offspring through methyl supplementation. J. Neurosci.25(47),11045–11054 (2005).Crossref, Medline, CAS, Google Scholar32 Benbrahim-Tallaa L, Waterland R, Styblo M, Achanzar W, Webber M, Waalkes MP: Molecular events associated with arsenic-induced malignant transformation of human prostatic epithelial cells: aberrant genomic DNA methylation and K-ras oncogene activation. Toxicol. Appl. Pharmacol.206(3),288–298 (2005).Crossref, Medline, CAS, Google Scholar33 Dolinoy DC, Weidman JR, Jirtle RL: Epigenetic gene regulation: linking early developmental environment to adult disease. Reprod. Toxicol. (2006) (Epub ahead of print).Medline, Google Scholar34 Reik W, Dean W, Walter J: Epigenetic reprogramming in mammalian development. Science293(5532),1089–1093 (2001).Crossref, Medline, CAS, Google Scholar35 Wolff G: Influence of maternal phenotype on metabolic differentiation of agouti locus mutants in the mouse. Genetics88(3),529–539 (1978).Crossref, Medline, CAS, Google Scholar36 Belyaev D, Ruvinsky A, Borodin P: Inheritance of alternative states of the fused gene in mice. J. Hered.72(2),107–112 (1981).Crossref, Medline, CAS, Google Scholar37 Blewitt ME, Vickaryous NK, Paldi A, Koseki H, Whitelaw E: Dynamic reprogramming of DNA methylation at an epigenetically sensitive allele in mice. PLoS Genet.2(4),49 (2006).Crossref, Medline, CAS, Google Scholar38 Drake AJ, Walker BR, Seckl JR: Intergenerational consequences of fetal programming by in utero exposure to glucocorticoids in rats. Am. J. Physiol. Regul. Integr. Comp. Physiol.288(1),R34–R38. (2005).Crossref, Medline, CAS, Google Scholar39 Newbold RR, Padilla-Banks E, Jefferson WN: Adverse effects of the model environmental estrogen diethylstilbestrol are transmitted to subsequent generations. Endocrinology147(6),S11–S17 (2006).Crossref, Medline, CAS, Google Scholar40 Koturbash I, Baker M, Loree J et al.: Epigenetic dysregulation underlies radiation-induced transgenerational genome instability in vivo. Int. J. Radiat. Oncol. Biol. Phys.66(2),327–330 (2006).Crossref, Medline, CAS, Google Scholar41 Pembrey ME, Bygren LO, Kaati G et al.: Sex-specific, male-line transgenerational responses in humans. Eur. J. Hum. Genet.14(2),159–166 (2006).Crossref, Medline, Google Scholar42 Anway MD, Cupp AS, Uzumcu M, Skinner MK: Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science308(5727),1466–1469 (2005).Crossref, Medline, CAS, Google Scholar43 Anway MD, Leathers C, Skinner MK: Endocrine disruptor vinclozolin induced epigenetic transgenerational adult-onset disease. Endocrinology147(12),5515–5523 (2006).Crossref, Medline, CAS, Google Scholar44 Chang H-S, Anway MD, Rekow SS, Skinner MK: Transgenerational epigenetic imprinting of the male germ line by endocrine disruptor exposure during gonadal sex determination. Endocrinology147(12),5524–5541 (2006).Crossref, Medline, CAS, Google Scholar45 Fraga MF, Ballestar E, Paz MF et al.: Epigenetic differences arise during the lifetime of monozygotic twins. Proc. Natl Acad. Sci. USA102(30),10604–10609 (2005).Crossref, Medline, CAS, Google Scholar46 Oates N, van Vliet J, Duffy D et al.: Increased DNA methylation at the AXIN1 gene in a monozygotic twin from a pair discordant for a caudal duplication anomaly. Am. J. Hum. Genet.79(1),155–162 (2006).Crossref, Medline, CAS, Google Scholar47 Luedi PP, Hartemink AJ, Jirtle RL: Genome-wide prediction of imprinted murine genes. Genome Res.15(6),875–884 (2005).Crossref, Medline, CAS, Google Scholar48 Eckhardt F, Lewin J, Cortese R et al.: DNA methylation profiling of human chromosomes 6, 20 and 22. Nat. Genet.38(12),1378–1385 (2006).Crossref, Medline, CAS, Google Scholar101 Human Epigenome Project homepage www.epigenome.org/index.phpGoogle ScholarFiguresReferencesRelatedDetailsCited ByIntervention during the first 1000 days in Mexico4 July 2020 | Nutrition Reviews, Vol. 78, No. Supplement_2Epigenetic Changes in Islets of Langerhans Preceding the Onset of Diabetes17 August 2020 | Diabetes, Vol. 69, No. 11Present and Future Pharmacological Treatments for Opioid Addiction10 June 2020DNA Methylation Changes Are Associated With an Incremental Ascent to High Altitude29 October 2019 | Frontiers in Genetics, Vol. 10Fetal Programming of Adult Disease in a Translational Point of View15 November 2019Predictors of folate status among pregnant Japanese women: the Hokkaido Study on Environment and Children's Health, 2002–201228 April 2016 | British Journal of Nutrition, Vol. 115, No. 12Serine Metabolism Supports the Methionine Cycle and DNA/RNA Methylation through De Novo ATP Synthesis in Cancer CellsMolecular Cell, Vol. 61, No. 2Probing the evolutionary history of epigenetic mechanisms: what can we learn from marine diatoms10 May 2021 | AIMS Genetics, Vol. 02, No. 03Erythrocyte folate concentrations, CpG methylation at genomically imprinted domains, and birth weight in a multiethnic newborn cohort29 May 2014 | Epigenetics, Vol. 9, No. 8Environmental epigenetics: from novelty to scientific discipline9 July 2013 | Journal of Applied Toxicology, Vol. 34, No. 2Principles of pharmacogeneticsA Look Backwards at Environmental Risk Assessment: An Approach to Reconstructing Ecological Exposures5 May 2012Epigenetic mechanisms in developmental programming of adult diseaseDrug Discovery Today, Vol. 16, No. 23-24The molecular and cellular basis of variable craniofacial phenotypes and their genetic rescue in Twisted gastrulation mutant miceDevelopmental Biology, Vol. 355, No. 1Epigenetics and Nutrition: B-Vitamin Deprivation and its Impact on Brain Amyloid31 January 2011A Methyl-Deficient Diet Fed to Rat Dams during the Peri-Conception Period Programs Glucose Homeostasis in Adult Male but Not Female Offspring24 November 2010 | The Journal of Nutrition, Vol. 141, No. 1Retinoblastoma as an Epigenetic Disease: A ProposalJournal of Cancer Therapy, Vol. 02, No. 03Fetal programming: link between early nutrition, DNA methylation, and complex diseasesNutrition Reviews, Vol. 68, No. 2Spectroscopic studies of STZ-induced methylated-DNA in both in vivo and in vitro conditionsSpectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, Vol. 71, No. 3Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment26 January 2008 | European Journal of Clinical Pharmacology, Vol. 64, No. 2 Vol. 8, No. 1 Follow us on social media for the latest updates Metrics Downloaded 374 times History Published online 22 December 2006 Published in print January 2007 Information© Future Medicine LtdAcknowledgementsThis work was supported by NIH grants ES13053, ES08823, ES015165, and T32-ES07031. The author declares no competing financial interests and thanks Randy L Jirtle for critical reading of the manuscript.PDF download

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