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Amyloid‐beta plaque growth in cognitively normal adults: Longitudinal [ 11 C]Pittsburgh compound B data

2011; Wiley; Volume: 70; Issue: 5 Linguagem: Inglês

10.1002/ana.22608

1531-8249

Andrei G. Vlassenko, Mark A. Mintun, Chengjie Xiong, Yvette I. Sheline, Alison Goate, Tammie L.S. Benzinger, John C. Morris,

Advanced Neuroimaging Techniques and Applications

Amyloid-beta (Aβ) accumulation was evaluated with 2 [(11)C]Pittsburgh compound B (PiB) positron emission tomography scans about 2.5 years apart in 146 cognitively normal adults. Seventeen of 21 participants with initially elevated Aβ deposition demonstrated subsequent Aβ plaque growth (approximately 8.0% per year), and none reverted to a state of no Aβ deposits. Ten individuals converted from negative to positive PiB status, based on a threshold of the mean cortical binding potential, representing a conversion rate of 3.1% per year. Individuals with an ε4 allele of apolipoprotein E demonstrated increased incidence of conversion (7.0% per year). Our findings suggest that the major growth in Aβ burden occurs during a preclinical stage of Alzheimer disease (AD), prior to the onset of AD-related symptoms.