Sonogashira Coupling Reaction with Diminished Homocoupling
2003; American Chemical Society; Volume: 5; Issue: 11 Linguagem: Inglês
10.1021/ol034320+
ISSN1523-7060
AutoresArumugasamy Elangovan, Yu‐Hsiang Wang, Tong‐Ing Ho,
Tópico(s)Chemical Synthesis and Analysis
Resumo[reaction: see text] The side product from homocoupling reaction of two terminal acetylenes in the Sonogashira reaction can be reduced to about 2% using an atmosphere of hydrogen gas diluted with nitrogen or argon. Terminal arylethynes, diarylethynes, and a few new arylpyridylethynes with donor substituents have been synthesized in very good yields. Comparative control experiments suggest that the homocoupling yield is determined by concentration of both catalyst and oxygen.
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