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BIBTEX RIS

Clinical and microbiological effects of systemic antimicrobials combined to an anti‐infective mechanical debridement for the management of aggressive periodontitis: a 12‐month randomized controlled trial

2012; Wiley; Volume: 40; Issue: 3 Linguagem: Inglês

10.1111/jcpe.12052

1600-051X

Mayra Xavier E Silva-Senem, Débora Heller, Victor Macedo Varela, Maria Cynésia Medeiros de Barros, Eduardo J. Feres‐Filho, Ana Paula Vieira Colombo,

Dental Research and COVID-19

Abstract Aim To compare the 1‐year clinical and microbiological outcomes of an enhanced anti‐infective therapy with versus without systemic antimicrobials in patients with generalized aggressive periodontitis (GAP). Methods In this 12‐month randomized, double‐blinded, placebo‐controlled trial, 35 individuals assigned to a control ( n = 17) or test group ( n = 18) received full‐mouth supra and subgingival ultrasonic debridement followed by scaling and root planing with chlorhexidine rinsing, brushing, and irrigation. Subjects received either amoxicillin (AMX, 500 mg) + metronidazole (MET, 250 mg) or placebos, TID for 10 days. Subgingival samples were obtained and analysed for their composition by checkerboard. Data were subjected to non‐parametric tests. Results Both therapeutic protocols resulted in similar significant clinical improvement for most parameters at 1 year ( p < 0.01). The AMX + MET group exhibited shallower residual pockets than the placebo ( p = 0.05). Most periodontal pathogens decreased, whereas beneficial bacteria increased in counts in both groups over time ( p < 0.0012). High levels of some periodontal and other microbial pathogens were associated with disease persistence regardless treatment. Conclusions The enhanced anti‐infective mechanical therapy is comparable with its combination with systemic AMX+MET for most clinical parameters and for maintaining low levels of periodontal pathogens for up to 1 year after treatment of GAP.