Fries rearrangement in methane sulfonic acid, an environmental friendly acid
2002; Elsevier BV; Volume: 182-183; Linguagem: Inglês
10.1016/s1381-1169(01)00506-4
ISSN1873-314X
AutoresAnnie Commarieu, Wolfgang F. Hoelderich, J.A. Laffitte, Marie-Pierre Dupont,
Tópico(s)Chemistry and Chemical Engineering
ResumoThe Fries rearrangement of phenyl acetate for the paracetamol process is usually performed in hydrofluoric acid (HF). We have optimized this reaction with methane sulfonic acid (MSA), a strong, stable and biodegradable acid, to give para-hydroxyacetophenone with high conversion and selectivity (up to 92% of para-isomer and 8% of ortho-isomer at 100% conversion).
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