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Studies on a new aminoglycoside antibiotic, dactimicin II. Isolation, structure and chemical degradation.

1981; Springer Nature; Volume: 34; Issue: 9 Linguagem: Inglês

10.7164/antibiotics.34.1090

1881-1469

Kazunori Ohba, Takashi Tsuruoka, Kazuko Mizutani, Noriko Kato, SHOJI OMOTO, Norio Ezaki, Shigeharu Inouye, TARO NIIDA, Kôji Watanabe,

Enzyme Catalysis and Immobilization

A new aminoglycoside antibiotic, dactimicin produced by a Dactylosporangium matsuzakiense SF-2052 has been isolated by column chromatography on a cation-exchange resin and CM-Sephadex. The structure of dactimicin was determined to be 4-amino-1, 4-dideoxy- 3 - O - (2, 6 - diamino-2, 3, 4, 6, 7 -pentadeoxy- β- L -lyxo-heptopyranosyl)-1-[(N-formimidoylglycyl)- methylamino]-6-O-methyl-L-chiro-inositol. Alkaline hydrolysis of dactimicin afforded 1-N -(N-formylglycyl)fortimicin B, fortimicin B, fortimicin A and an acyl migration product, 2'-N-(N-formylglycyl)fortimicin B.