Changing the Palladium Coordination to Phosphinoimidazolines with a Remote Triazole Substituent
2011; Wiley; Volume: 353; Issue: 18 Linguagem: Inglês
10.1002/adsc.201100684
ISSN1615-4169
AutoresVerónica de la Fuente, Rocı́o Marcos, Xacobe C. Cambeiro, Sergio Castillón, Carmen Claver, Miquel À. Pericàs,
Tópico(s)Chemical Synthesis and Analysis
ResumoAbstract Phosphinoimidazoline (PHIM) ligands bearing a triazolylmethyl substituent at the sp 3 nitrogen atom in the imidazoline ring lead to highly improved enantioselectivity (up to 99% ee ) in allylic substitution reactions with respect to analogous ligands with substituents lacking the triazole unit. NMR and theoretical studies support a shift in the coordination mode of the PHIM ligand to palladium, triggered by a very favourable interaction with the triazole unit.
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