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In Vitro Bioactive Characteristics of Borate‐Based Glasses with Controllable Degradation Behavior

2006; Wiley; Volume: 90; Issue: 1 Linguagem: Inglês

10.1111/j.1551-2916.2006.01358.x

1551-2916

Aihua Yao, Deping Wang, Wenhai Huang, Qiang Fu, Mohamed N. Rahaman, Delbert E. Day,

Spine and Intervertebral Disc Pathology

Silicate‐based bioactive glasses undergo incomplete conversion to a calcium phosphate material after in vivo implantation, which severely limits their biomedical application. In this communication, novel borate‐based glasses with controllable degradation behavior were developed and their bioactive potential was investigated in vitro . When immersed in a 0.02 M K 2 HPO 4 solution at 37°C, these glasses reacted to form a carbonate‐substituted hydroxyapatite (c‐HA) on their surfaces, indicating their bioactive potential. The conversion rate to c‐HA was controlled by adjusting the B 2 O 3 /SiO 2 ratio in the glass composition. The results indicate the potential application of the borate‐based bioactive glass as scaffold materials for bone tissue engineering.