Artigo Acesso aberto Revisado por pares

Entomologic and Virologic Investigation of Chikungunya, Singapore

2009; Centers for Disease Control and Prevention; Volume: 15; Issue: 8 Linguagem: Inglês

10.3201/eid1508.081486

ISSN

1080-6059

Autores

Lee Ching Ng, Li-Kiang Tan, Cheong Huat Tan, Sharon S.Y. Tan, Hapuarachchige Chanditha Hapuarachchi, Kwoon-Yong Pok, Yee-Ling Lai, Sai-Gek Lam-Phua, Göran Bucht, Raymond Tzer Pin Lin, Yee‐Sin Leo, Boon Huan Tan, Hwi-Kwang Han, Peng-Lim S Ooi, Lyn James, Seow-Poh Khoo,

Tópico(s)

Malaria Research and Control

Resumo

Abstract Local transmission of chikungunya, a debilitating mosquito-borne viral disease, was first reported in Singapore in January 2008. After 3 months of absence, locally acquired Chikungunya cases resurfaced in May 2008, causing an outbreak that resulted in a total of 231 cases by September 2008. The circulating viruses were related to East, Central, and South African genotypes that emerged in the Indian Ocean region in 2005. The first local outbreak was due to a wild-type virus (alanine at codon 226 of the envelope 1 gene) and occurred in an area where Aedes aegypti mosquitoes were the primary vector. Strains isolated during subsequent outbreaks showed alanine to valine substitution (A226V) and largely spread in areas predominated by Ae. albopictus mosquitoes. These findings led to a revision of the current vector control strategy in Singapore. This report highlights the use of entomologic and virologic data to assist in the control of chikungunya in disease-endemic areas.

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