Produção Nacional
Revisado por pares
Linkage disequilibrium patterns and genetic structure of Amerindian and non‐Amerindian Brazilian populations revealed by long‐range X‐STR markers
2009; Wiley; Volume: 139; Issue: 3 Linguagem: Inglês
10.1002/ajpa.20998
ISSN1096-8644
AutoresFabio P.N. Leite, Sidney Emanuel Batista dos Santos, Elzemar M.R. Rodríguez, Sidia M. Callegari‐Jacques, Darío Alfredo Demarchi, Luiza Tamie Tsuneto, Maria Luiza Petzl‐Erler, Francisco M. Salzano, Mara Helena Hutz,
Tópico(s)Genetic Associations and Epidemiology
ResumoAbstract The extent of X‐chromosome linkage disequilibrium (LD) was studied in a southern Brazilian population, and in a pool of samples from Amerindian populations. For this purpose, 11 microsatellites, located mostly in a Xq region comprising ∼86 Mb was investigated. The lower Amerindian gene diversity associated with significant differences between the populations studied indicated population structure as the main cause for the higher LD values in the Amerindian pool. On the other hand, the LD levels of the non‐Amerindian Brazilian sample, although less extensive than that of the Amerindians, were probably determined by admixture events. Our results indicated that different demographic histories have significant effects on LD levels of human populations, and provide a first approach to the X‐chromosome ancestry of Amerindian and non‐Amerindian Brazilian populations, being valuable for future studies involving mapping and population genetic studies. Am J Phys Anthropol 2009. © 2009 Wiley‐Liss, Inc.
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