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Noninvasive Analysis of Myocardial Function Using High-Resolution Doppler Tissue Echocardiography in Rats

2005; Elsevier BV; Volume: 18; Issue: 5 Linguagem: Inglês

10.1016/j.echo.2005.01.035

1097-6795

Mikiko Shimizu, Igor E. Konstantinov, Andrew M. Suess, Michael Cheung, Brian W. McCrindle, Michael Vogel, Andrew N. Redington,

Cardiovascular Effects of Exercise

The widespread use of rodent models of cardiovascular disease has demanded improved methods of assessing myocardial function. Recently, invasive measurement of cardiac function using conductance catheterization has become available for assessing ventricular performance in small animals. 1 Feldman M.D. Mao Y. Valvano J.W. Pearce A.J. Freeman L.G. Development of a multifrequency conductance catheter-based system to determine LV function in mice. Am J Physiol Heart Circ Physiol. 2000; 48: H1411 Google Scholar , 2 Dimitrios G. Kass D. Estimation of parallel conductance by dual-frequency conductance catheter in mice. Am J Physiol. 2000; 279: H443-H450 Google Scholar , 3 Ito H. Takaki M. Yamaguchi H. Tachibana H. Suga H. Left ventricular volumetric conductance catheter for rats. Am J Physiol. 1996; 39: H1509 Google Scholar However, although pressure-volume loop analysis has become the gold standard, it is impractical for longitudinal assessment of disease or interventions. The ideal method under these circumstances would be noninvasive, an accurate index of contractile function, resistant to the influence of load, and reproducibly measurable in small animals.