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Astrocytes Couple Synaptic Activity to Glucose Utilization in the Brain

1999; American Physiological Society; Volume: 14; Issue: 5 Linguagem: Inglês

10.1152/physiologyonline.1999.14.5.177

1548-9213

Pierre J. Magistretti, Luc Pellerin,

Memory and Neural Mechanisms

Astrocytes have functional characteristics that make them particularly well suited to couple glutamate uptake from the synaptic cleft to Na(+)-K(+)-ATPase activation and glucose utilization. The changes in glucose metabolism associated with these processes may provide signals detected by positron emission tomography.