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Loss of Mismatched HLA in Leukemia after Stem-Cell Transplantation

2009; Massachusetts Medical Society; Volume: 361; Issue: 5 Linguagem: Inglês

10.1056/nejmoa0811036

1533-4406

Luca Vago, Serena K. Perna, Monica Zanussi, Benedetta Mazzi, Cristina Barlassina, Maria Teresa Lupo Stanghellini, Nicola Flavio Perrelli, Cristian Cosentino, Federica Torri, Andrea Angius, Barbara Forno, Monica Casucci, Massimo Bernardi, Jacopo Peccatori, Consuelo Corti, Attilio Bondanza, Maurizio Ferrari, Silvano Rossini, Maria Grazia Roncarolo, Claudio Bordignon, Chiara Bonini, Fabio Ciceri, Katharina Fleischhauer,

T-cell and B-cell Immunology

Transplantation of hematopoietic stem cells from partially matched family donors is a promising therapy for patients who have a hematologic cancer and are at high risk for relapse. The donor T-cell infusions associated with such transplantation can promote post-transplantation immune reconstitution and control residual disease.