Octopamine-sensitive adenylate cyclase in haemocytes of the forest tent caterpillar, Malacosoma disstria Hubner (Lepidoptera: Lasiocampidae)
1982; NRC Research Press; Volume: 60; Issue: 5 Linguagem: Inglês
10.1139/z82-113
ISSN1480-3283
AutoresJ.W.D. Gole, Roger Downer, S. S. Sohi,
Tópico(s)Neurobiology and Insect Physiology Research
ResumoInjection of octopamine into the haemocoel of third instar larvae and pupae of the forest tent caterpillar, Malacosoma disstria, results in a rapid elevation of haemolymph cyclic AMP levels. The elevated cyclic AMP levels are due, at least in part, to the action of octopamine on haemocytes, as evidenced by the octopamine-induced stimulation of adenylate cyclase in an established haemocyte cell line (Md 66). The effect is simulated by the adrenergic agonist, synephrine, and inhibited by the α-adrenergic blocking agent, phentolamine. The insect haemocyte receptor–enzyme system resembles equivalent vertebrate systems in being activated by sodium fluoride and requiring GTP for expression of effector-induced activation of the enzyme.
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