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Panax ginseng extract improves scopolamine‐induced deficits in working memory performance in the T‐maze delayed alternation task in rats

1993; Wiley; Volume: 7; Issue: 1 Linguagem: Inglês

10.1002/ptr.2650070112

1099-1573

Xiao-Hu Ni, Hiroyuki Ohta, H. Watanabe, Kinzo Matsumoto,

Pharmacological Effects of Natural Compounds

Abstract The effects of Panax ginseng water extract on spatial working memory disruption induced by scopolamine were examined using a T‐maze delayed alternation task in rats. Scopolamine (0.025–0.1 mg/kg, i.p.) dose‐dependently impaired the maze performance, and physostigmine (0.4 mg/kg) significantly reversed the scopolamine (0.1 mg/kg)‐induced performance deficits. Ginseng extract (0.5–4.0 g dried root/kg) orally administered 60 min before testing dose‐dependently improved the maze performance disrupted by scopolamine (0.1 mg/kg). Ginseng extract given for 7 days in drinking water (2.0 and 4.0 g/kg/day) also exhibited dose‐dependent reversal of the scopolamine‐induced performance deficits. These data indicate the beneficial effects of ginseng extract on spatial working memory in rats.