Paradoxical Reactions to Benzodiazepines: Literature Review and Treatment Options
2004; Wiley; Volume: 24; Issue: 9 Linguagem: Inglês
10.1592/phco.24.13.1177.38089
ISSN1875-9114
AutoresCarissa E. Mancuso, Maria G. Tanzi, Michael Gabay,
Tópico(s)Anesthesia and Sedative Agents
ResumoBenzodiazepines frequently are administered to patients to induce sedation. Paradoxical reactions to benzodiazepines, characterized by increased talkativeness, emotional release, excitement, and excessive movement, are relatively uncommon and occur in less than 1% of patients. The exact mechanism of paradoxical reactions remains unclear. Most cases are idiosyncratic; however, some evidence suggests that these reactions may occur secondary to a genetic link, history of alcohol abuse, or psychological disturbances. This review evaluates the numerous cases of paradoxical reactions to benzodiazepines in adult and pediatric patients that have been reported in the biomedical literature. It also explores the advantages and disadvantages of the various available treatment options.
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