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A Randomized Trial of Candidate Inactivated Quadrivalent Influenza Vaccine versus Trivalent Influenza Vaccines in Children Aged 3–17 Years

2013; Oxford University Press; Volume: 207; Issue: 12 Linguagem: Inglês

10.1093/infdis/jit091

1537-6613

Joseph B. Domachowske, Heidemarie Pankow-Culot, Milagros Bautista, Yang Feng, Carine Claeys, Mathieu Peeters, Bruce L. Innis, Varsha Jain,

Pneumonia and Respiratory Infections

Background. Two antigenically distinct influenza B lineages have cocirculated since 2001, yet trivalent influenza vaccines (TIVs) contain 1 influenza B antigen, meaning lineage mismatch with the vaccine is frequent. We assessed a candidate inactivated quadrivalent influenza vaccine (QIV) containing both B lineages vs TIV in healthy children aged 3–17 years.