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BIBTEX RIS

In vitro trypanocidal evaluation of pinane derivatives from essential oils of ripe fruits from Schinus terebinthifolius Raddi (Anacardiaceae)

2012; Brazilian Chemical Society; Volume: 35; Issue: 4 Linguagem: Inglês

10.1590/s0100-40422012000400017

ISSN

1678-7064

Autores

Patrı́cia Sartorelli, Jeferson Santos Santana, Rafael C. Guadagnin, João Henrique G. Lago, Érika G. Pinto, André G. Tempone, Hélio A. Stefani, Marisi G. Soares, A.A. Silva,

Tópico(s)

Toxin Mechanisms and Immunotoxins

Resumo

Essential oils of ripe fruits from Schinus terebinthifolius (Anacardiaceae), obtained using a pilot extractor and a Clevenger apparatus were chemically characterized. Due the high amount of (-)- α-pinene in both oils, this monoterpene was tested against the protozoan parasite Trypanosoma cruzi, showing a moderate potential (IC50 63.56 µg/mL) when compared to benznidazole (IC50 43.14 µg/mL). Otherwise, (-)- α-pinene oxide did not showed anti-trypanosomal activity (IC50 > 400 µg/mL) while (-)-pinane showed an IC50 of 56.50 µg/mL. The obtained results indicated that the epoxydation of α-pinene results to the loss of the anti-parasitic activity while its hydrogenation product, contributed slightly to the increased activity.

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