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Total Synthesis and Biological Evaluation of (−)‐Englerin A and B: Synthesis of Analogues with Improved Activity Profile

2011; Wiley; Volume: 50; Issue: 17 Linguagem: Inglês

10.1002/anie.201007790

1521-3773

Lea Radtke, Matthieu Willot, Hongyan Sun, Slava Ziegler, Stephanie Sauerland, Carsten Strohmann, Roland Fröhlich, Peter Habenberger, Herbert Waldmann, Mathias Christmann,

Marine Sponges and Natural Products

The large-scale synthesis of englerin A (see scheme) and subsequent structure-activity relationship studies have led to the discovery of highly potent analogues. TBS=tert-butyldimethylsilyl. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.