Portal de Periódicos da CAPES

Primary cilia signaling mediates intraocular pressure sensation

2014; National Academy of Sciences; Volume: 111; Issue: 35 Linguagem: Inglês

10.1073/pnas.1323292111

1091-6490

Na Luo, Michael Conwell, Xingjuan Chen, Christine Insinna Kettenhofen, Christopher J. Westlake, Louis B. Cantor, Clark D. Wells, Robert N. Weinreb, Timothy W. Corson, Dan F. Spandau, Karen M. Joos, Carlo Iomini, Alexander G. Obukhov, Yang Sun,

Neuroscience of respiration and sleep

Significance This study defines a cellular mechanism by which primary cilia mediate mechanosensation in intraocular pressure regulation. Changes in pressure are sensed by the interaction of the inositol phosphatase OCRL with transient receptor potential vanilloid 4 (TRPV4), a primary cilia-based calcium channel. Pediatric glaucoma (Lowe) syndrome patient cells with defective OCRL failed to respond to agonists of TRPV4, and targeting of TRPV4 lowered intraocular pressure in vivo. These findings significantly advance the current understanding of how intraocular pressure is regulated.