Fluorine in medicinal chemistry
2007; Royal Society of Chemistry; Volume: 37; Issue: 2 Linguagem: Inglês
10.1039/b610213c
ISSN1460-4744
AutoresSophie Purser, Peter R. Moore, Steve Swallow, Véronique Gouverneur,
Tópico(s)Synthesis and Reactions of Organic Compounds
ResumoIt has become evident that fluorinated compounds have a remarkable record in medicinal chemistry and will play a continuing role in providing lead compounds for therapeutic applications. This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion clarifying the role and impact of fluorine substitution on drug potency.
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