Portal de Periódicos da CAPES

Antitrypanosomal activity of a novel norlignan purified from Nectandra lineata

2005; Taylor & Francis; Volume: 19; Issue: 4 Linguagem: Inglês

10.1080/1478641042000261950

1478-6427

Lilia Chérigo, Venancio Polanco, Eduardo Ortega-Barrı́a, María V. Heller, Todd L. Capson, Luis Cubilla‐Rios,

Phytochemical compounds biological activities

Bioactivity-guided fractionation of a MeOH-EtOAc extract from the young leaves of Nectandra lineata (Lauraceae), using a Trypanosoma cruzi bioassay resulted in the isolation of a novel norlignan 3'-methoxy-3,4-methylenedioxy-4',7-epoxy-9-nor-8,5'-neolignan-9'-acetoxy (1), together with the known compound, 3'-methoxy-3,4-methylenedioxy-4'-7-epoxy-9-nor-8,5'-neolignan-7,8'-diene (2). Compounds 1 and 2 were shown to inhibit the growth of T. cruzi epimastigotes in axenic culture.