Artigo Revisado por pares

Parallel Synthesis of Sialyl Lewis X Mimetics on a Solid Phase: Access to a Library of Fucopeptides

1998; Wiley; Volume: 37; Issue: 12 Linguagem: Inglês

10.1002/(sici)1521-3773(19980703)37

ISSN

1521-3773

Autores

Thomas Lampe, Gabriele Weitz‐Schmidt, Chi‐Huey Wong,

Tópico(s)

Carbohydrate Chemistry and Synthesis

Resumo

Angewandte Chemie International EditionVolume 37, Issue 12 p. 1707-1711 Communication Parallel Synthesis of Sialyl Lewis X Mimetics on a Solid Phase: Access to a Library of Fucopeptides Thomas F. J. Lampe, Thomas F. J. Lampe The Scripps Research Institute, Department of Chemistry, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA), Fax: (+1) 619-784-2409Search for more papers by this authorGabriele Weitz-Schmidt, Gabriele Weitz-Schmidt Novartis Pharma AG, Preclinical Research, CH-4002 Basel (Switzerland)Search for more papers by this authorChi-Huey Wong, Chi-Huey Wong The Scripps Research Institute, Department of Chemistry, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA), Fax: (+1) 619-784-2409Search for more papers by this author Thomas F. J. Lampe, Thomas F. J. Lampe The Scripps Research Institute, Department of Chemistry, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA), Fax: (+1) 619-784-2409Search for more papers by this authorGabriele Weitz-Schmidt, Gabriele Weitz-Schmidt Novartis Pharma AG, Preclinical Research, CH-4002 Basel (Switzerland)Search for more papers by this authorChi-Huey Wong, Chi-Huey Wong The Scripps Research Institute, Department of Chemistry, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA), Fax: (+1) 619-784-2409Search for more papers by this author First published: 17 December 1998 https://doi.org/10.1002/(SICI)1521-3773(19980703)37:12 3.0.CO;2-VCitations: 28AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract A novel anchoring group p-(acyloxymethyl)benzylidene acetal (p-AMBA) enables the bidirectional functionalization of glycosylated amino acid derivatives and thus the rapid parallel synthesis of fucopeptides as sialyl Lewis X mimetics on a solid phase [Eq. (a), PEG-PS=poly(ethylene glycol) graft copolymer]. This led to the discovery of new mimetics against P-selectin with IC50 values in the low μM range. Citing Literature Volume37, Issue12July 3, 1998Pages 1707-1711 RelatedInformation

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