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Comparison of SCOUT DS, the ADA Diabetes Risk Test and Random Capillary Glucose for Diabetes Screening in At-Risk Populations

2013; Elsevier BV; Volume: 37; Linguagem: Inglês

10.1016/j.jcjd.2013.08.239

2352-3840

John Maynard, Andrea Barrack, Paul Murphree, Panagiotis Lathouris, Nikolaοs Tentolouris, Stauroula Londou, Carole A. Paley, Mandy Swanepoel, Richard S. Pope,

Diabetes and associated disorders

Screening at-risk subjects for prediabetes and diabetes is an important step in prevention efforts. We examined the accuracy of random capillary glucose (RCG) and 2 noninvasive screening methods, SCOUT DS and the ADA diabetes risk test (DRT) for detecting increasing levels of abnormal A1C. We pooled studies performed in the US, UK and Greece that shared methods and aims. A diabetes score was calculated from skin fluorescence measured on the left forearm with SCOUT DS. A finger prick was done to measure RCG and A1C. Age, sex, history of gestational diabetes, family history of diabetes, history of hypertension, physical activity, height and weight were used for the DRT. Dysglycemia was defined as A1C≥6.0% and diabetes as A1C≥6.5%. 1161 subjects had complete data for analysis with means for age and BMI of 50 years and 29 kg/m2. Thirty-one percent were male. Prevalence of A1C≥6.0% and ≥6.5% were 17% and 5%, respectively. Sensitivity, specificity and AUC for detection of dysglycemia and diabetes are below:Tabled 1ThresholdA1C≥6.0%A1C≥6.5%SENSSPECAUCSENSSPECAUCSCOUT DS50 AU.79.67.81.95.62.90ADA DRT5.85.59.78.95.54.84RCG100 mg/dL.59.64.67.74.62.75 Open table in a new tab SCOUT DS and the ADA DRT had significantly greater AUC and sensitivity relative to RCG for detecting A1C-defined dysglycemia and diabetes. SCOUT DS had comparable AUC and sensitivity relative to the ADA DRT with significantly higher specificity. Both noninvasive tests outperformed RCG with the added advantages of no blood or pain.