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Sequence amplification and gene rearrangement in parasitic nematode mitochondrial DNA.

1988; Oxford University Press; Volume: 120; Issue: 3 Linguagem: Inglês

10.1093/genetics/120.3.707

1943-2631

Bradley C. Hyman, Joyce L. Beck, Kimberly Weiss,

Mitochondrial Function and Pathology

Abstract The nematode Romanomermis culicivorax, an obligate mosquito parasite, possesses a 26 kilobase (kb) mitochondrial genome. The unusually large size is due to transcriptionally active DNA sequences present as 3.0 kb direct tandem repeats and as inverted portions of the repeating unit located elsewhere in the mitochondrial DNA (mtDNA). The genome rearrangements involved in establishing this unusual sequence organization may have dramatically altered conventional mitochondrial gene order. Genes for subunits of the cytochrome c oxidase complex (COI and COII) are normally closely linked in animal mtDNAs, but are separated by approximately 8 kb in this mitochondrial genome.