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Comparative Effectiveness Research in Oncology: An Overview

2012; Lippincott Williams & Wilkins; Volume: 30; Issue: 34 Linguagem: Inglês

10.1200/jco.2012.45.9792

1527-7755

Gary H. Lyman, Mark N. Levine,

Cancer Genomics and Diagnostics

This Special Issue of Journal of Clinical Oncology provides a broad, in-depth look at the methodologic field that has become known as comparative effectiveness research (CER). The focus is on CER and its past, current, and future impact on cancer research, clinical oncology practice, and national health care policy. An extraordinary assemblage of authorities on a broad range of related topics has been gathered. The authors address issues ranging from those very familiar to oncologists and cancer researchers, such as randomized controlled trials and meta-analyses of such trials, to somewhat less familiar methodologies such as observational studies, decision modeling, and economic analyses of health care policy issues. The importance of our rapidly evolving understanding of the human genome and the molecular and genetic basis of new diagnostic and therapeutic tools will be discussed, along with the multiple challenges that they bring to CER. Important methodologic issues will be addressed, such as capturing patient-reported outcomes, conducting health technology assessments, and developing clinical guidelines to improve the quality of care. Finally, the manner in which CER has affected health care delivery and its cost, both in the United States and other developed nations such as Canada and the United Kingdom, will be discussed. The issue will end on a cautionary but positive note, reconciling the many varied approaches and expectations of CER as we strive to provide the most sophisticated and efficacious cancer care to all patients affected by this disease.