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Prevention of inflammation-mediated bone loss in murine and canine periodontal disease via recruitment of regulatory lymphocytes

2013; National Academy of Sciences; Volume: 110; Issue: 46 Linguagem: Inglês

10.1073/pnas.1302829110

1091-6490

Andrew J. Glowacki, Sayuri Yoshizawa, Siddharth Jhunjhunwala, Andreia Espíndola Vieira, Gustavo Pompermaier Garlet, Charles Sfeir, Steven R. Little,

Oral microbiology and periodontitis research

Significance Periodontal disease (gum disease) is an extremely prevalent inflammatory disease initiated by persistent bacterial insult, leading to the destruction of bone and gingival tissues. Current clinical treatments focus solely on the removal of bacteria. In this study, we put forth a strategy to address the underlying inflammatory imbalance in periodontal disease by harnessing the body’s own sophisticated immunoregulatory mechanisms through the recruitment of regulatory T cells (Tregs). This is accomplished by controllably releasing small quantities (nanogram/kilogram range) of chemokine recognized by Tregs using biodegradable, resorbable polymers with an excellent track record of regulatory approval. Administration of Treg-recruiting treatments to the gingiva of mice and canines reduces clinical scores of disease as well as hard and soft tissue destruction.