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Direct Magnesiation of Polyfunctionalized Arenes and Heteroarenes Using (tmp) 2 Mg⋅2 LiCl

2007; Wiley; Volume: 46; Issue: 40 Linguagem: Inglês

10.1002/anie.200701487

1521-3773

Giuliano C. Clososki, Christoph J. Rohbogner, Paul Knochel,

Catalytic C–H Functionalization Methods

Outstripping lithium bases: A wide range of polyfunctional aryl and heteroaryl magnesium reagents were efficiently prepared in THF by direct magnesiation with (tmp)2Mg⋅2 LiCl, an exceptionally active base. These compounds can serve as intermediates in natural product synthesis. In the example shown a palladium-catalyzed cross-coupling reaction is used to prepare a derivative of salicylic acid. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z701487_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.