Long-Term Evaluation of Metabolic Profile and Bone Mineral Density After Ileocystoplasty in Children
2003; Lippincott Williams & Wilkins; Volume: 170; Issue: 4 Part 2 Linguagem: Inglês
10.1097/01.ju.0000083887.58315.7e
ISSN1527-3792
AutoresAshraf T. Hafez, Gordon A. McLorie, DAVID GILDAY, Bernd Laudenberg, Jyoti Upadhyay, Darius Bägli, Antoine E. Khoury,
Tópico(s)Pediatric Urology and Nephrology Studies
ResumoNo AccessJournal of UrologyCLINICAL UROLOGY: Bladder Augmentation/Reconstruction1 Oct 2003Long-Term Evaluation of Metabolic Profile and Bone Mineral Density After Ileocystoplasty in Children ASHRAF T. HAFEZ, GORDON McLORIE, DAVID GILDAY, BERND LAUDENBERG, JYOTI UPADHYAY, DARIUS BÄGLI, and ANTOINE E. KHOURY ASHRAF T. HAFEZASHRAF T. HAFEZ , GORDON McLORIEGORDON McLORIE , DAVID GILDAYDAVID GILDAY , BERND LAUDENBERGBERND LAUDENBERG , JYOTI UPADHYAYJYOTI UPADHYAY , DARIUS BÄGLIDARIUS BÄGLI , and ANTOINE E. KHOURYANTOINE E. KHOURY View All Author Informationhttps://doi.org/10.1097/01.ju.0000083887.58315.7eAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We evaluated the long-term effects of ileocystoplasty on linear growth, serum electrolytes, acid-base profile and bone mineral density (BMD) in a group of neurologically intact children with a mean followup of 8.9 years. Materials and Methods: Between 1988 and 1997, 9 girls and 16 boys with a mean age of 6 years (range 1 month to 14 years) underwent ileocystoplasty for etiologies other than myelomeningocele and neuropathic bladder. Indications for ileocystoplasty were small noncompliant bladder secondary to bladder exstrophy in 12 cases, bladder outlet obstruction in 10 and post-partial cystectomy for rhabdomyosarcoma in 3. All patients underwent clinical evaluation, supine height measurement, serum electrolytes, arterial blood gases and BMD measurement using a fan beam dual energy absorpitometry scan. BMD was measured at L1–L4 and corrected for age and sex. Results: Followup ranged from 4 to 13 years (mean 8.9). Serum creatinine was normal in 20 of the 25 patients. All patients had normal supine height measurement with a mean of 45th (± 9) centile on growth charts. Serum electrolytes, calcium, phosphorus and arterial blood gases were normal in all patients. Mean BMD corrected for age and sex was 89 (± 10)%. BMD was normal in 17 of 25 (68%) patients. Mild reduction in bone density between 1 and 2 standard deviations below the age/sex mean was documented in 3 (12%) patients and the remaining 5 (20%) showed marked osteopenia of 2 or more standard deviations. Of the latter 5 patients 2 had increased serum creatinine, 1 had a history of radiotherapy for pelvic rhabdomyosarcoma and 2 had cloacal exstrophy and short bowel, all of which might have contributed to the osteopenia. Conclusions: Ileocystoplasty for children with normal kidney function is not associated with alterations in serum electrolytes or arterial blood gases in the long term. However, 32% of patients showed variable degrees of reduction in BMD. Although marked reduction in BMD was associated with cofactors, 12% of patients had evidence of mild osteopenia in absence of those cofactors. 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Google Scholar From the Divisions of Urology and Nuclear Medicine, Hospital of Sick Children, University of Toronto, Toronto, Ontario, Canada© 2003 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited bySchlomer B, Saperston K and Baskin L (2013) National Trends in Augmentation Cystoplasty in the 2000s and Factors Associated with Patient OutcomesJournal of Urology, VOL. 190, NO. 4, (1352-1358), Online publication date: 1-Oct-2013.Scales C and Wiener J (2018) Evaluating Outcomes of Enterocystoplasty in Patients With Spina Bifida: A Review of the LiteratureJournal of Urology, VOL. 180, NO. 6, (2323-2329), Online publication date: 1-Dec-2008.Neel K, Soliman S, Salem M, Seida M, Al-Hazmi H and Khatab A (2018) Botulinum-A Toxin: Solo Treatment for Neuropathic Noncompliant BladderJournal of Urology, VOL. 178, NO. 6, (2593-2598), Online publication date: 1-Dec-2007.Lendvay T, Cowan C, Mitchell M, Joyner B and Grady R (2018) Augmentation Cystoplasty Rates at Children’s Hospitals in the United States: A Pediatric Health Information System Database StudyJournal of Urology, VOL. 176, NO. 4S, (1716-1720), Online publication date: 1-Oct-2006.Gilbert S and Hensle T (2018) RE: METABOLIC CONSEQUENCES AND LONG-TERM COMPLICATIONS OF ENTEROCYSTOPLASTY IN CHILDREN: A REVIEWJournal of Urology, VOL. 174, NO. 5, (2070-2071), Online publication date: 1-Nov-2005.Gerharz E and Roosen A (2018) RE: METABOLIC CONSEQUENCES AND LONG-TERM COMPLICATIONS OF ENTEROCYSTOPLASTY IN CHILDREN: A REVIEWJournal of Urology, VOL. 174, NO. 5, (2070-2070), Online publication date: 1-Nov-2005. Volume 170Issue 4 Part 2October 2003Page: 1639-1642 Advertisement Copyright & Permissions© 2003 by American Urological Association, Inc.Keywordsbone mineral densitybladderaugmentationsMetricsAuthor Information ASHRAF T. HAFEZ More articles by this author GORDON McLORIE More articles by this author DAVID GILDAY More articles by this author BERND LAUDENBERG More articles by this author JYOTI UPADHYAY More articles by this author DARIUS BÄGLI More articles by this author ANTOINE E. KHOURY More articles by this author Expand All Advertisement PDF downloadLoading ...
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