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BIBTEX RIS

No aggravation of renal injury in apolipoprotein E knockout mice (ApoE-/-) after subtotal nephrectomy

2004; Oxford University Press; Volume: 19; Issue: 3 Linguagem: Inglês

10.1093/ndt/gfg578

ISSN

1460-2385

Autores

Moriz Buzello, Christian Haas, Felix Hauptmann, M.-L. Gross, J. Faulhaber, Stefan Schultze‐Mosgau, Heimo Ehmke, Eberhard Ritz, K. Amann,

Tópico(s)

Renal and Vascular Pathologies

Resumo

Background. There is substantial experimental evidence that various forms of dyslipidaemia aggravate the course of renal failure and that reversal of dyslipidaemia ameliorates progression of renal failure. The apolipoprotein E knockout mouse (ApoE–/–) is an established model of accelerated atherogenesis. We investigated whether the course of renal disease after uninephrectomy (UNX) and subtotal nephrectomy (SNX) is altered in ApoE–/– mice compared with their genetic controls.

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