Behaviour of cells mutant for an EGF receptor homologue of Drosophila in genetic mosaics
1990; Royal Society; Volume: 242; Issue: 1303 Linguagem: Inglês
10.1098/rspb.1990.0100
ISSN1471-2954
AutoresFernando J. Díaz‐Benjumea, Antonio Garcı́a-Bellido,
Tópico(s)melanin and skin pigmentation
ResumoRestricted accessMoreSectionsView PDF ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InRedditEmail Cite this article Díaz-Benjumea F. J. and García-Bellido A. 1990Behaviour of cells mutant for an EGF receptor homologue of Drosophila in genetic mosaicsProc. R. Soc. Lond. B.24236–44http://doi.org/10.1098/rspb.1990.0100SectionRestricted accessArticleBehaviour of cells mutant for an EGF receptor homologue of Drosophila in genetic mosaics F. J. Díaz-Benjumea Google Scholar Find this author on PubMed Search for more papers by this author and A. García-Bellido Google Scholar Find this author on PubMed Search for more papers by this author F. J. Díaz-Benjumea Google Scholar Find this author on PubMed and A. García-Bellido Google Scholar Find this author on PubMed Published:22 October 1990https://doi.org/10.1098/rspb.1990.0100AbstractThe Drosophila homologue of the epidermal growth factor receptor (DEGFr or DER, also called torpedo or top) has many mutant alleles that cause either embryonic lethality (both early and late), pupal lethality or female sterility, possibly corresponding to degrees of hypomorphism. We have studied the clonal behaviour of some lethal alleles in genetic mosaics in the imaginal development of thorax, head and tergite epidermis. These alleles cause reduced cell viability to different degrees (measured in frequency and size of clones), smaller cell sizes, abnormal patterning of sensory-organ differentiation and lack of differentiation of macro-chaetae and veins. These effects are cellautonomous but also cause abnormal differentiation in wild-type cells surrounding the clones. In addition, we have studied the phenotypes of double mutant combinations of viable top alleles with wingpattern mutants, some related to other Drosophila proto-oncogenes, to reveal gene interactions in the role(s) of DER in cell proliferation and differentiation. We discuss how those complex cell-behaviour phenotypes and genetic interactions are related to the molecular nature of the DER.FootnotesThis text was harvested from a scanned image of the original document using optical character recognition (OCR) software. As such, it may contain errors. Please contact the Royal Society if you find an error you would like to see corrected. Mathematical notations produced through Infty OCR. 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