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Disposition of sulfonamides in food‐producing animals: pharmacokinetics of sulfamerazine in cattle

1978; Wiley; Volume: 1; Issue: 4 Linguagem: Inglês

10.1111/j.1365-2885.1978.tb00341.x

1365-2885

G. D. KORITZ, David W. A. Bourne, Lewis W. Dittert, R. F. Bevill,

Pharmacological Effects and Assays

The disposition of sulfamerazine in the plasma and urine of cattle was determined following single intravenous and oral doses. The averaged and the individual animal data were described by a two‐compartment pharmacokinetic model. The drug was eliminated with a biological half‐life of 6.2 h, primarily by renal excretion of unchanged sulfamerazine and metabolism to acetylsulfamerazine. Sulfamerazine (in solution) was absorbed with a half‐life 6.7 h and with relative completeness (68%) following oral administration.