Ketamine: An Introduction for the Pain and Palliative Medicine Physician
2007; American Society of Interventional Pain Physicians; Volume: 3;10; Issue: 5;3 Linguagem: Inglês
10.36076/ppj.2007/10/493
ISSN2150-1149
Autores Tópico(s)Pain Management and Opioid Use
ResumoA history of an escalating chronic intractable pain in a patient with cryoglobulinemia, vasculitis, and severe cutaneous ulcerations is presented. A strategy of progressive, multi-agent, N-methyl-D-aspartate-receptor (NMDA-R) blockade that resulted in adequate pain control and a three-fold reduction in opioid consumption is described. Diagnostic process of neuropathic pain and the role of NMDA-R in the development of hyperalgesia are briefly reviewed. Thereafter, existing clinical literature describing the use of Ketamine, a major NMDA-R antagonist for management of malignant pain, is reviewed. Lastly, evidence-based original protocol for intravenous adjuvant Ketamine analgesia for severe cancer pain is presented. Key Words: Cancer, Ketamine, pain
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