Portal de Periódicos da CAPES

Physiology of Iron Metabolism

2014; Karger Publishers; Volume: 41; Issue: 3 Linguagem: Inglês

10.1159/000362888

1660-3818

Sophie Waldvogel‐Abramowski, Gérard Waeber, Christoph Gassner, Andreas Buser, Beat M. Frey, Bernard Favrat, Jean‐Daniel Tissot,

Trace Elements in Health

A revolution occurred during the last decade in the comprehension of the physiology as well as in the physiopathology of iron metabolism. The purpose of this review is to summarize the recent knowledge that has accumulated, allowing a better comprehension of the mechanisms implicated in iron homeostasis. Iron metabolism is very fine tuned. The free molecule is very toxic; therefore, complex regulatory mechanisms have been developed in mammalian to insure adequate intestinal absorption, transportation, utilization, and elimination. ‘Ironomics' certainly will be the future of the understanding of genes as well as of the protein-protein interactions involved in iron metabolism.