Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease
2010; BioMed Central; Volume: 3; Issue: 1 Linguagem: Inglês
10.1186/alzrt59
ISSN1758-9193
AutoresRandall J. Bateman, Paul Aisen, Bart De Strooper, Nick C. Fox, Cynthia A. Lemere, John M. Ringman, Stephen Salloway, Reisa A. Sperling, Manfred Windisch, Chengjie Xiong,
Tópico(s)Dementia and Cognitive Impairment Research
ResumoAutosomal-dominant Alzheimer's disease has provided significant understanding of the pathophysiology of Alzheimer's disease. The present review summarizes clinical, pathological, imaging, biochemical, and molecular studies of autosomal-dominant Alzheimer's disease, highlighting the similarities and differences between the dominantly inherited form of Alzheimer's disease and the more common sporadic form of Alzheimer's disease. Current developments in autosomal-dominant Alzheimer's disease are presented, including the international Dominantly Inherited Alzheimer Network and this network's initiative for clinical trials. Clinical trials in autosomal-dominant Alzheimer's disease may test the amyloid hypothesis, determine the timing of treatment, and lead the way to Alzheimer's disease prevention.
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